PHARMACOLOGY-II

UNIT-I

1. Pharmacology of drugs acting on cardio vascular system 

a. Introduction to hemodynamic and electrophysiology of heart. 

b. Drugs used in congestive heart failure 

c. Anti-hypertensive drugs. 

d. Anti-anginal drugs. 

e. Anti-arrhythmic drugs. 

f. Anti-hyperlipidemic drugs. 

UNIT-II

1. Pharmacology of drugs acting on cardio vascular system 

a. Drug used in the therapy of shock. 

b. Hematinics, coagulants and anticoagulants. 

c. Fibrinolytics and anti-platelet drugs 

d. Plasma volume expanders 

2. Pharmacology of drugs acting on urinary system

a. Diuretics 

b. Anti-diuretics

UNIT-III 

3. Autocoids and related drugs 

a. Introduction to autacoids and classification 

b. Histamine, 5-HT and their antagonists. 

c. Prostaglandins, Thromboxanes and Leukotrienes. 

d. Angiotensin, Bradykinin and Substance P. 

e. Non-steroidal anti-inflammatory agents 

f.  Anti-gout drugs 

g. Antirheumatic drugs

UNIT-IV

5. Pharmacology of drugs acting on endocrine system 

a. Basic concepts in endocrine pharmacology. 

b. Anterior Pituitary hormones- analogues and their inhibitors. 

c. Thyroid hormones- analogues and their inhibitors. 

d. Hormones regulating plasma calcium level- Parathormone, Calcitonin andVitamin-D.

e. Insulin, Oral Hypoglycemic agents and glucagon.

f. ACTH and corticosteroids.

UNIT-V

5. Pharmacology of drugs acting on endocrine system 

a. Androgens and Anabolic steroids. 

b. Estrogens, progesterone and oral contraceptives. 

c. Drugs acting on the uterus. 

6. Bioassay 

a. Principles and applications of bioassay. 

b.Types of bioassay 

c. Bioassay of insulin, oxytocin, vasopressin, ACTH, d-tubocurarine,digitalis, histamineand 5-HT.

PRACTICAL

1. Introduction to in-vitro pharmacology and physiological salt solutions. 

2. Effect of drugs on isolated frog heart. 

3. Effect of drugs on blood pressure and heart rate of dog. 

4. Study of diuretic activity of drugs using rats/mice. 

5. DRC of acetylcholine using frog rectus abdominis muscle. 

6. Effect of physostigmine and atropine on DRC of acetylcholine using frog rectus abdominis muscle and rat ileum respectively. 

7. Bioassay of histamine using guinea pig ileum by matching method. 

8. Bioassay of oxytocin using rat uterine horn by interpolation method. 

9. Bioassay of serotonin using rat fundus strip by three point bioassay. 

10. Bioassay of acetylcholine using rat ileum/colon by four point bioassay. 

11. Determination of PA2 value of prazosin using rat anococcygeus muscle (by Schilds plot method). 

12. Determination of PD2 value using guinea pig ileum. 

13. Effect of spasmogens and spasmolytics using rabbit jejunum. 

14. Anti-inflammatory activity of drugs using carrageenan induced paw-edema model. 

15. Analgesic activity of drug using central and peripheral methods 

Note: All laboratory techniques and animal experiments are demonstrated by simulated experiments by softwares and videos

Recommended Books (Latest Editions) 

1. Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rang and Dale’s Pharmacology, Churchil Livingstone Elsevier 

2. Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc Graw-Hill. 

3. Goodman and Gilman’s, The Pharmacological Basis of Therapeutics 

4. Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A. K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs, The Point Lippincott Williams & Wilkins. 

5. Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews- Pharmacology. 

6. K.D.Tripathi. Essentials of Medical Pharmacology, , JAYPEE Brothers Medical Publishers (P) Ltd, New Delhi. 

7. Sharma H. L., Sharma K. K., Principles of Pharmacology, Paras medical publisher 

8. Modern Pharmacology with clinical Applications, by Charles R.Craig& Robert. 

9. Ghosh MN. Fundamentals of Experimental Pharmacology. Hilton & Company, Kolkata. 

10. Kulkarni SK. Handbook of experimental pharmacology. Vallabh Prakashan.