NOVEL DRUG DELIVERY SYSTEMS

NEW* NOVEL DRUG DELIVERY SYSTEM COMPLETE STUDY MATERIAL

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No.of Pages: 233

Language: Simple & Plain English

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Unit-I  

Controlled drug delivery systems:

Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. 

Physicochemical and biological properties of drugs relevant to controlled release formulations 

Polymers: 

Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems. 

Unit-II 

Microencapsulation:

Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications 

Mucosal Drug Delivery system:

Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems 

Implantable Drug Delivery Systems:

Introduction, advantages and disadvantages, concept of implantsand osmotic pump 

Unit-III 

Transdermal Drug Delivery Systems: 

Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches 

Gastroretentive drug delivery systems: 

Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications 

Nasopulmonary drug delivery system: 

Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers 

Unit-IV 

Targeted drug Delivery: 

Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications 

Unit-V

Ocular Drug Delivery Systems: 

Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts 

Intrauterine Drug Delivery Systems: 

Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications 

Recommended Books: (Latest Editions) 

1. Y W. Chien, Novel Drug Delivery Systems, 2 nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992. 

2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992. 

3. Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim 

4. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edition 1997 (reprint in 2001).

5. S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances, Vallabh Prakashan, New Delhi, First edition 2002. 

Journals 

1. Indian Journal of Pharmaceutical Sciences (IPA) 

2. Indian Drugs (IDMA) 

3. Journal of Controlled Release (Elsevier Sciences) 

4. Drug Development and Industrial Pharmacy (Marcel & Decker) 

5. International Journal of Pharmaceutics (Elsevier Sciences)