PHARMACOLOGY-III

UNIT-I

1. Pharmacology of drugs acting on Respiratory system 

a. Anti -asthmatic drugs 

b. Drugs used in the management of COPD 

c. Expectorants and antitussives 

d. Nasal decongestants 

e. Respiratory stimulants 

2. Pharmacology of drugs acting on the Gastrointestinal Tract 

a. Antiulcer agents. 

b. Drugs for constipation and diarrhoea. 

c. Appetite stimulants and suppressants. 

d. Digestants and carminatives. 

e. Emetics and anti-emetics. 

UNIT-II 

3. Chemotherapy 

a. General principles of chemotherapy. 

b. Sulfonamides and cotrimoxazole. 

c. Antibiotics- Penicillins, cephalosporins, chloramphenicol, macrolides, quinolones and fluoroquinolins, tetracycline and aminoglycosides 

UNIT-III

3. Chemotherapy 

a. Antitubercular agents 

b. Antileprotic agents

c. Antifungal agents 

d. Antiviral drugs 

e.Anthelmintics 

f. Antimalarial drugs 

g. Antiamoebic agents 

UNIT-IV

3. Chemotherapy

 l. Urinary tract infections and sexually transmitted diseases. 

m. Chemotherapy of malignancy. 

4. Immunopharmacology 

a. Immunostimulants 

b. Immunosuppressant Protein drugs, monoclonal antibodies, target drugs to antigen, biosimilars 

UNIT-V

5. Principles of toxicology

a. Definition and basic knowledge of acute, subacute and chronic toxicity. 

b. Definition and basic knowledge of genotoxicity, carcinogenicity, teratogenicity and mutagenicity 

c. General principles of treatment of poisoning 

d. Clinical symptoms and management of barbiturates, morphine, organophosphosphorus compound and lead, mercury and arsenic poisoning. 

6. Chronopharmacology 

a. Definition of rhythm and cycles. 

b. Biological clock and their significance leading to chronotherapy. 

PRACTICAL

1. Dose calculation in pharmacological experiments 

2. Antiallergic activity by mast cell stabilization assay 

3. Study of anti-ulcer activity of a drug using pylorus ligand (SHAY) rat model and NSAIDS induced ulcer model. 

4. Study of effect of drugs on gastrointestinal motility 

5. Effect of agonist and antagonists on guinea pig ileum 

6. Estimation of serum biochemical parameters by using semi- autoanalyser 

7. Effect of saline purgative on frog intestine 

8. Insulin hypoglycemic effect in rabbit 

9. Test for pyrogens ( rabbit method) 

10. Determination of acute oral toxicity (LD50) of a drug from a given data 

11. Determination of acute skin irritation / corrosion of a test substance 

12. Determination of acute eye irritation / corrosion of a test substance 

13. Calculation of pharmacokinetic parameters from a given data 

14. Biostatistics methods in experimental pharmacology( student’s t test, ANOVA) 

15. Biostatistics methods in experimental pharmacology (Chi square test, Wilcoxon Signed Rank test) 

*Experiments are demonstrated by simulated experiments/videos 

Recommended Books (Latest Editions) 

1. Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rang and Dale’s Pharmacology, Churchil Livingstone Elsevier

2. Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc Graw-Hill 

3. Goodman and Gilman’s, The Pharmacological Basis of Therapeutics 

4. Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A. K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs. The Point Lippincott Williams & Wilkins 

5. Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews- Pharmacology 

6. K.D.Tripathi. Essentials of Medical Pharmacology, , JAYPEE Brothers Medical Publishers (P) Ltd, New Delhi. 

7. Sharma H. L., Sharma K. K., Principles of Pharmacology, Paras medical publisher Modern Pharmacology with clinical Applications, by Charles R.Craig& Robert, 

8. Ghosh MN. Fundamentals of Experimental Pharmacology. Hilton & Company, Kolkata, 

9. Kulkarni SK. Handbook of experimental pharmacology. VallabhPrakashan, 10. N.Udupa and P.D. Gupta, Concepts in Chronopharmacology.