PHARMACEUTICAL ORGANIC CHEMISTRY –III

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Includes : 5 Unit complete handwritten notes

Important Questions with answers in each Unit

Additional questions with answers

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Written By : A Bavatharani (M Pharm)

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No.of pages : 182

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UNIT-I 

Stereo isomerism (Handwritten Notes)

• Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds 
• Elements of symmetry, chiral and achiral molecules 
• DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers 
• Reactions of chiral molecules 
• Racemic modification and resolution of racemic mixture. 
• Asymmetric synthesis: partial and absolute 

UNIT-II 

Geometrical isomerism 

• Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) 
• Methods of determination of configuration of geometrical isomers. 
• Conformational isomerism in Ethane, n-Butane and Cyclohexane. 
• Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. 
• Stereospecific and stereoselective reactions 

UNIT-III

Heterocyclic compounds: 

• Nomenclature and classification 
• Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene 
• Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene 

UNIT-IV 

Synthesis, reactions and medicinal uses of following compounds/derivatives 

       Pyrazole, Imidazole, Oxazole and Thiazole. 

       Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives 

UNIT-V 

Reactions of synthetic importance 

• Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction. 
• Oppenauer-oxidation and Dakin reaction. 
• Beckmanns rearrangement and Schmidt rearrangement. 
• Claisen-Schmidt condensation.

Recommended Books (Latest Editions) 

1. Organic chemistry by I.L. Finar, Volume-I & II. 

2. A text book of organic chemistry – Arun Bahl, B.S. Bahl.

3. Heterocyclic Chemistry by Raj K. Bansal 

4. Organic Chemistry by Morrison and Boyd 

5. Heterocyclic Chemistry by T.L. Gilchrist